2-BroMooxazole-4-carboxylic acid

2-BroMooxazole-4-carboxylic acid - Names and Identifiers

Name	4-Oxazolecarboxylicacid, 2-broMo-
Synonyms	2-BroMooxazole-4-carboxylic acid 2-bromo-4-Oxazolecarboxylic acid 4-Oxazolecarboxylicacid, 2-broMo- 2-bromo-1,3-oxazole-4-carboxylic acid
CAS	1167055-73-3

2-BroMooxazole-4-carboxylic acid - Physico-chemical Properties

Molecular Formula	C4H2BrNO3
Molar Mass	191.97
Density	2.038±0.06 g/cm3(Predicted)
Boling Point	363.0±34.0 °C(Predicted)
pKa	3.00±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

2-BroMooxazole-4-carboxylic acid - Reference Information

Application

2-bromooxazole-4-carboxylic acid can be used as a pharmaceutical synthesis intermediate, it can be prepared by reacting ethyl 2-bromooxazole-4-carboxylate with lithium hydroxide as a reaction raw material. 2-bromooxazole-4-carboxylic acid can be used to prepare IRAK inhibitors.

preparation

2-bromooxazole-4-carboxylic acid the preparation is as follows: 2-bromooxazole-4-carboxylic acid ethyl ester (2.5g,11.36mmo) was dissolved in THF/methanol mixture (9: 1) and 1m lithium hydroxide (22.73ml,22.73mmol) was added slowly. The reaction mixture was stirred at room temperature for 1 H, diluted with water and the pH was adjusted to 2. The formed precipitate was filtered and dried to give the title compound (1.1g). The filtrate was extracted three times with ethyl acetate. The ethyl acetate phases were combined, dried and evaporated to dryness to give 0.85g of the title compound 2-bromooxazole-4-carboxylic acid. The overall yield was 88%.

Last Update：2024-04-09 15:16:57